VISA (gene)

Mitochondrial antiviral signaling protein

Identifiers

MAVS; CARDIF; DKFZp547C224; DKFZp666M015; FLJ27482; FLJ31698; FLJ35386; FLJ38051; FLJ41962; IPS-1; IPS1; KIAA1271; MGC3260; VISA

External IDs

OMIM: 609676 MGI: 2444773 HomoloGene: 17004 GeneCards: MAVS Gene

Gene Ontology
Molecular function	• signal transducer activity • protein binding • protein kinase binding • CARD domain binding
Cellular component	• mitochondrion • mitochondrial outer membrane • mitochondrial outer membrane • mitochondrial outer membrane • membrane • integral to membrane
Biological process	• positive regulation of protein phosphorylation • activation of innate immune response • positive regulation of defense response to virus by host • positive regulation of defense response to virus by host • signal transduction • response to virus • negative regulation of type I interferon production • positive regulation of interferon-alpha production • positive regulation of interferon-alpha production • positive regulation of interferon-beta production • positive regulation of interferon-beta production • positive regulation of interleukin-8 production • positive regulation of tumor necrosis factor production • positive regulation of protein import into nucleus, translocation • defense response to bacterium • positive regulation of transcription factor import into nucleus • positive regulation of I-kappaB kinase/NF-kappaB cascade • interspecies interaction between organisms • innate immune response • positive regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of type I interferon-mediated signaling pathway • cellular response to exogenous dsRNA • positive regulation of chemokine (C-C motif) ligand 5 production • positive regulation of IP-10 production
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
3.83 – 3.85 Mb

Chr 2:
131.06 – 131.07 Mb

PubMed search

[1]

[2]

Mitochondrial antiviral-signaling protein (MAVS) is a protein that in humans is encoded by the MAVS gene.^[1]^[2]^[3] The protein is also known by the names VISA (virus-induced signaling adapter), IPS-1 and Cardif. Aggregated MAVS form protease resistant prion-like aggregates that activate IRF3 dimerization. ^[4]

NCBI Refseq summary of MAVS

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005).[supplied by OMIM]^[3]

References

^ Seth RB, Sun L, Ea CK, Chen ZJ (Sep 2005). "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3". Cell 122 (5): 669–82. doi:10.1016/j.cell.2005.08.012. PMID 16125763.
^ Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB (Sep 2005). "VISA is an adapter protein required for virus-triggered IFN-beta signaling". Mol Cell 19 (6): 727–40. doi:10.1016/j.molcel.2005.08.014. PMID 16153868.
^ ^a ^b "Entrez Gene: VISA virus-induced signaling adapter". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57506.
^ Hou, F; Sun, L, Zheng, H, Skaug, B, Jiang, QX, Chen, ZJ (2011 Aug 5). "MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.". Cell 146 (3): 448–61. doi:10.1016/j.cell.2011.06.041. PMC 3179916. PMID 21782231. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3179916.

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Kawai T, Takahashi K, Sato S, et al. (2005). "IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.". Nat. Immunol. 6 (10): 981–8. doi:10.1038/ni1243. PMID 16127453.
Meylan E, Curran J, Hofmann K, et al. (2005). "Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.". Nature 437 (7062): 1167–72. doi:10.1038/nature04193. PMID 16177806.
Li XD, Sun L, Seth RB, et al. (2006). "Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity.". Proc. Natl. Acad. Sci. U.S.A. 102 (49): 17717–22. doi:10.1073/pnas.0508531102. PMC 1308909. PMID 16301520. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1308909.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Loo YM, Owen DM, Li K, et al. (2006). "Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.". Proc. Natl. Acad. Sci. U.S.A. 103 (15): 6001–6. doi:10.1073/pnas.0601523103. PMC 1458687. PMID 16585524. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1458687.
Cheng G, Zhong J, Chisari FV (2006). "Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms.". Proc. Natl. Acad. Sci. U.S.A. 103 (22): 8499–504. doi:10.1073/pnas.0602957103. PMC 1482521. PMID 16707574. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1482521.
Lin R, Lacoste J, Nakhaei P, et al. (2006). "Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage.". J. Virol. 80 (12): 6072–83. doi:10.1128/JVI.02495-05. PMC 1472616. PMID 16731946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1472616.
Saha SK, Pietras EM, He JQ, et al. (2006). "Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.". EMBO J. 25 (14): 3257–63. doi:10.1038/sj.emboj.7601220. PMC 1523175. PMID 16858409. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1523175.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Opitz B, Vinzing M, van Laak V, et al. (2007). "Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication.". J. Biol. Chem. 281 (47): 36173–9. doi:10.1074/jbc.M604638200. PMID 16984921.
Chen Z, Benureau Y, Rijnbrand R, et al. (2007). "GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS.". J. Virol. 81 (2): 964–76. doi:10.1128/JVI.02076-06. PMC 1797450. PMID 17093192. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1797450.
Hirata Y, Broquet AH, Menchén L, Kagnoff MF (2007). "Activation of innate immune defense mechanisms by signaling through RIG-I/IPS-1 in intestinal epithelial cells.". J. Immunol. 179 (8): 5425–32. PMID 17911629.

VISA (gene)

NCBI Refseq summary of MAVS

References

Further reading